Unasyn Oral

Manufacturer: Pfizer
Pharmaceutical name: Sultamicillin tosylate
Pack: 12 tablets (375mg/tab)


Manufacturer: Pfizer
Pack: 12 tabs (375mg/tab)

Therapeutic actions of Unasyn Oral:
The addition of sulbactam, a beta-lactamase inhibitor, to ampicillin extends the spectrum of ampicillin to include some beta-lactamase producing organisms; Unasyn Oral inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

What is Unasyn Oral used for?:
• Sultamicillin tosylate treats Skin and Skin Structure Infections;
• Sultamicillin tosylate treats Intra-Abdominal Infections;
• Sultamicillin tosylate treats Gynecological Infections.

Contraindications and cautions when taking Unasyn Oral:
• allergy to any ingredient in Unasyn or any other penicillin antibiotic (eg, amoxicillin);
• taking a tetracycline antibiotic (eg, doxycycline) together with Sultamicillin tosylate;
• mononucleosis;
• caution if EBV, CMV infection;
• caution if ALL;
• caution if hypersens. to cephalosporins;
• caution if impaired renal fxn;
• caution if hyperuricemia;

Side effects of Sultamicillin tosylate:
The following side effects may occur when using Sultamicillin tosylate diarrhea; pain, swelling, or redness at injection site.

Interactions of Sultamicillin tosylate with other medicines:
• Unasyn 's effectiveness may be decreased by tetracyclines (eg, doxycycline);
• Allopurinol may increase the risk of skin rash;
• Heparin may increase the risk of bleeding;
• Unasyn may increase the risk of side effects of methotrexate;
• Unasyn may decrease effectiveness or increase the risk of their side effects of anticoagulants (eg, warfarin);
• Unasyn may decrease effectiveness of aminoglycosides (eg, gentamicin) or oral contraceptives (eg, ethinyl estradiol/norethindrone).