Brand Fempro (Letrozole)

Fempro is product from Cipla Pharmaceuticals and used mainly with other medications to treat certain types of breast cancer (e.g., hormone-receptor-positive breast cancer) in women after menopause. Fempro (Letrozole) is also used to help prevent the cancer from returning. Some breast cancers are made due to grow faster by a natural hormone in women's body called estrogen. Fempro (Letrozole) decreases the amount of estrogen made by the body and helps to slow or reverse the growth of these breast cancers.

Directions
Hepatic Impairment
No dosage adjustment is recommended for patients with mild or moderate hepatic impairment, although letrozole blood concentrations were modestly increased in subjects with moderate impairment due to cirrhosis. The dose of letrozole in patients with cirrhosis and severe hepatic dysfunction should be reduced by 50%. The recommended dose for such patients is 2.5mg administered every other day.

Precautions
Ask from your doctor and pharmacist if you are allergic to letrozole, any other medications, or any of the inactive ingredients in letrozole tablets.
You should know that letrozole should only be used by women who have experienced menopause and cannot become pregnant. However, if you are pregnant or breastfeeding, you should tell your doctor before you begin taking this medication. Use a reliable method of birth control to prevent pregnancy during your treatment. Letrozole may harm the fetus.
You should know that letrozole may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
The recommended dose of Fempro tablets is one 2.5mg tablet administered once daily with or without food. No dose adjustment is required for elderly patients.

Side Effects

• Hot flushes
• Night sweats
• Nausea
• Vomiting
• Muscle, joint, or bone pain
• Excessive tiredness
• Headache
• Dizziness
• Muscle weakness
• Swelling of the hands, feet, ankles, or lower legs
• Loss of appetite
• Constipation
• Diarrhea
• Stomach pain
• Difficulty falling asleep or staying asleep
• Vaginal bleeding or irritation
• Breast pain
• Flu-like symptoms
• Difficulty urinating
• Pain on urination
• Cough
• Rash

Overdose Information
Isolated cases of letrozole overdose have been reported. In these instances, the highest single dose ingested was 62.5mg or 25 tablets. No serious adverse events were reported in these cases. Because of the limited data available, no firm recommendations for treatment can be made and therefore you should contact your doctor or health professional immediately.