Manufacturer: Cipla, India
Pharmaceutical name: Pack: 1 tab (300 mg)
Uses For Lamivudine and Zidovudine
Lamivudine and zidovudine combination is used in the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS).
Lamivudine and zidovudine combination will not cure or prevent HIV infection or the symptoms of AIDS; however, it helps keep HIV from reproducing, and appears to slow down the destruction of the immune system. This may help delay the development of serious health problems usually related to AIDS or HIV infection. Lamivudine and zidovudine combination will not keep you from spreading HIV to other people. People who receive lamivudine and zidovudine may continue to have other problems usually related to AIDS or HIV infection.
The effectiveness of either lamivudine or zidovudine when used alone may decrease as the HIV virus develops resistance to the effects of the individual drugs. By combining lamivudine and zidovudine, it is more difficult for the HIV virus to develop resistance to therapy since it must develop resistance to both drugs.
Storage:
Store at 2-30°C (36-86°F).
Dosing:
For the treatment of HIV infection the recommended oral dose for adults or children greater than 12 years of age is one tablet twice daily. Lamivudine and Zidovudine is administered without regard to meals since food does not affect its absorption.
Drug Interactions:
Fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote) reduce the elimination of zidovudine and therefore increase the blood concentration of zidovudine. This can lead to increased side effects from zidovudine.
Side Effects:
The most serious side effects of Lamivudine and Zidovudine are a decrease in blood cells, muscle pain (myopathy) or muscle breakdown (rhabdomyolysis), liver enlargement and metabolic disturbance (lactic acidosis). Other side effects include chills, rash, abdominal pain, nausea and vomiting, weight loss, headache, cough and insomnia. Accumulation or redistribution of fat may also occur.
